Section 5 of Part 2: Can Nutrient Deficiencies Contribute To ALS Symptoms And How Is This Associated With A Gluten intolerance?
In individuals with celiac disease, the immune system reacts when gluten is ingested. The small intestinal villi, responsible for absorbing nutrients, become damaged, creating a flattened mucosal surface (villus flattening) that is less able to absorb nutrients. Autoimmune reactions to ingested gluten, cross-react with intestinal villi and this leads to the villi damage. Various nutrient deficiencies can occur, and this can affect every physiological system, including the neurological symptom.
With celiac disease (and in some with dermatitis herpetiformis), severity of nutrient loss and related symptoms are dependent on the location, length and severity of intestinal villi damage, which can be patchy in nature. As well, the presence of other factors such as diarrhea, vomiting, medications that affect nutrient absorption, a nutrient poor diet, other associated diseases, the presence of dysphasia, intestinal parasites, a poor diet, past stomach and intestinal surgery, smoking, or excessive alcohol intake could negatively affect nutrient levels. Nutrient deficiencies can also be present in non-celiac gluten intolerance if any of these influencing factors are present.
With nutrient deficiencies, many neurological symptoms can occur. Without treatment, the damage may become permanent. With gluten intolerance as a possible underlying cause of ALS, it is reasonable to suspect that low nutrient levels could add to the severity of ALS symptoms or lead to additional symptoms. Nutrient deficiencies contributing to neurological symptoms can include vitamins E, B complex, K, amino and fatty acids, calcium, magnesium, phosphorus, copper, electrolytes, l-carnitine, and inositol.
People with ALS may want to discuss this possibility with their doctor. Testing for a gluten intolerance along with treatment of underlying nutrient deficiencies might help to alleviate the symptoms associated with ALS. For those who are suffering, it may be worth ruling this out.
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The rest of Part 2, along with parts, 3, 4, and 5 will follow in the next 6-8 weeks. Scroll down the right side of my blog until you find ALS. All of the ALS posts will be found in this category.
5 Part Series
Part 1 Of 5 Part Series : Could A Gluten Intolerance Cause Amyotrophic Lateral Sclerosis (ALS) Or Lou Gehrig’s Disease?
Part 2 Of 5 Part ALS Series: How Could A Gluten Intolerance Cause Amyotrophic Lateral Sclerosis (ALS) Or Lou Gehrig’s Disease? (see 8 sections of Part 2 below)
Section 1 of Part 2: How Could Antibody Reactions Against Transglutaminases Contribute To ALS
Section 2 of Part 2: Could IgA and IgG Mediated reactions To Foods Contribute To ALS Symptoms
Section 3 of Part 2: Could Glutamic Acid And Aspartic Acid Contribute To ALS Symptoms
Section 4 of Part 2: Abnormal Neurological Findings With A Gluten Intolerance
Section 5 of Part 2: Can Nutrient Deficiencies Contribute And How is This Associated With A Gluten intolerance?
Section 6 of Part 2: Are There studies Showing An Association Between Gluten And ALS?
Part 3 Of 5 Part Series: How Could A Gluten Intolerance Cause ALS In Various Age Groups
Part 4 Of 5 Part Series: How could A Lectin Intolerance Contribute To ALS
Part 5 Of 5 Part Series: Some Final Thoughts About ALS And Gluten
Scroll down the right side of my blog until you find ALS. All of the ALS posts will be found in this category.
1. Gibney MJ, Vorster HH, Kok FJ. Introduction to Human Nutrition. Blackwell Publishing 2002.
2. Gibney MJ, Marinos E, Olle L, Dowsett J. Clinical Nutrition. Blackwell Publishing 2005.