Section 4 of Part 2: How Abnormal Neurological Findings Associated With A Gluten Intolerance Could Be Responsible For Amyotrophic Lateral Sclerosis (ALS) or Lou Gehrig’s Disease Symptoms
Gluten Intolerance can cause neurological damage throughout the body. Initially, the immune system reacts against gluten, but then cross reacts against tissue and cells in the peripheral and central nervous system. Sometimes, the damage can be permanent. Other times, it resolves once a strict gluten-free diet is maintained (it can take a year or more to work). As well, nutrient supplements may be required to treat deficiencies and other allergies may need to be identified and treated.
With a gluten intolerance, some abnormal findings on tests can include abnormal brain waves on electroencephalography (EEG), unusual cerebellar (part of brain) physiology, hypoperfused brain regions (decreased blood flow), brain atrophy (decreased size), inflammation, patchy Purkinje cell (out-put neurons) loss in the cerebellum, and progressive multifocal leukoencephalopathy leading to destruction of myelin sheaths that support neuronal impulses. Other findings include lymphocytic (immune system players) infiltration of the cerebellum and peripheral nerves, damage to the posterior columns of the spinal cord, and widespread IgA deposition around vessels in the brain (showing immune activity). As well, brain white-matter lesions or calcifications, likely resulting from autoimmune reactions, calcium deposits, ischemia (inadequate blood supply), vasculitis (inflammation of blood vessels), or inflammatory demyelination, can occur.
These findings can result in many neurological symptoms throughout the body that can be similar to ALS symptoms. Since ALS is a neurological disease, it is reasonable to suspect that the damage evident with a gluten intolerance may also be responsible for the symptoms associated with ALS. Patient’s dealing with this condition may want to take steps to rule out this possibility by testing for a gluten intolerance along with testing for other allergies and for any nutrient deficiencies (underlying celiac disease can cause this). The rest of this series of posts will discuss other possibilities as well.
Gluten ataxia is one type of gluten intolerance that can occur. The neurological damage with gluten ataxia results from immunological damage to the cerebellum, posterior columns of the spinal cord, and peripheral nerves. This can lead to neurological symptoms throughout the body.
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The rest of Part 2, along with parts, 3, 4, and 5 (see blow) will follow in the next 2-3 months. Scroll down the right side of my blog until you find ALS. All of the ALS posts will be found in this category.
5 Part Series
Part 1 Of 5 Part Series : Could A Gluten Intolerance Cause Amyotrophic Lateral Sclerosis (ALS) Or Lou Gehrig’s Disease?
Part 2 Of 5 Part ALS Series: How Could A Gluten Intolerance Cause Amyotrophic Lateral Sclerosis (ALS) Or Lou Gehrig’s Disease? (see 8 sections of Part 2 below)
Section 1 of Part 2: How Could Antibody Reactions Against Transglutaminases Contribute To ALS
Section 2 of Part 2: Could IgA and IgG Mediated reactions To Foods Contribute To ALS Symptoms
Section 3 of Part 2: Could Glutamic Acid And Aspartic Acid Contribute To ALS Symptoms
Section 4 of Part 2: How Abnormal Neurological Findings With A Gluten Intolerance Could be Associated With Amyotrophic Lateral Sclerosis (ALS) or Lou Gehrig’s Disease
Section 5 of Part 2: Can Nutrient Deficiencies Contribute And How is This Associated With A Gluten intolerance?
Section 7 of Part 2: Are There studies Showing An Association Between Gluten And ALS?
Part 3 Of 5 Part Series: How Could A Gluten Intolerance Cause ALS In Various Age Groups
Part 4 Of 5 Part Series: How could A Lectin Intolerance Contribute To ALS
Part 5 Of 5 Part Series: Some Final Thoughts About ALS And Gluten
Scroll down the right side of my blog until you find ALS. All of the ALS posts will be found in this category.
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