Part 11 of 12 Part Series: List of Diseases/Syndromes Associated With Celiac Disease
This is the eleventh in a series of posts discussing the variety of symptoms that can be caused by undiagnosed Celiac Disease (CD). In this post, a list of associated diseases/syndromes will be included. Individuals with Celiac Disease have a higher risk of developing other autoimmune diseases. This may be due to genetic influences or the heightened permeability of the intestine may allow other environmental antigens access to the immune system. This could lead to an autoimmune response that triggers the development of other autoimmune diseases (5,69). Delayed diagnosis appears to increase the risk as well. Therefore, early recognition and diagnosis is important for primary prevention.
List of Associated Diseases And Syndromes
Hashimoto’s Disease (Hypothyroidism) (1-5)
Grave’s Disease (Hyperthyroidism) (1-5)
Type 1 Diabetes (insulin dependent) (1-5,43)
Addison’s Disease (1,6,8)
Primary Biliary Cirrhosis (1,9-13)
Down’s Syndrome (1,4,)
Turner Syndrome (1)
William’s Syndrome (1)
Primary Adrenal Insufficiency (7,72)
IgA Nephropathy (44,45)
IgA Deficiency (1)
Alopecia Areata (1)
Sjögren’s Syndrome (1,42)
Cardiomyopathy (1,55-60)
Malignancy (1)
Vasculitis (18,63)
Antiphospholipid Syndrome (17,33,61,62)
Thrombocytopenic Purpura (ITP) (67,68)
Systemic Sclerosis (19)
Some individuals may be misdiagnosed with systemic lupus erythematosus (1,4,14-17,70,71), fibromyalgia (1), or polymyalgia rheumatica (1) since these diseases have similar symptoms. Others may only have their CD symptoms diagnosed as irritable bowel (1-4), lactose intolerance (1,3,4,20), arthritis (1,35-39), miscarriages, infertility (1,4,21-25), osteoporosis (1-4,40,41), aphthous stomatitis (1-4), anemia (1-4), failure to thrive (1-4), various skin rashes (1-4,18), ataxia (1,26-32), epilepsy (1,26-32), and/or myopathies (34,46-54). There are many other possible symptoms and diseases with similar symptoms that are discussed in the 12 part series.
I recommend waiting until CD/gluten sensitivity testing is complete before initiating a gluten-free diet because it may create a false negative. If your CD test is negative, you may still have a gluten sensitivity. Discuss this with your MD or specialist. Review your symptoms and everything in this post with a Medical Doctor and your specialists before you make any changes. Your MD knows your medical history and the treatments that are appropriate for you.
References
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67. Ola Olén?1,2†, Scott M. Montgomery
?3,45, Göran Elinder
?1,2, Anders Ekbom
?3,6 and Jonas F. Ludvigsson
?3,7 Increased risk of immune thrombocytopenic purpura among inpatients with coeliac disease. Scandinavian Journal of Gastroenterology 2008, Vol. 43, No. 4, Pages 416-422.
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70. Rensch M.J. et el. The Prevalence Of Celiac Disease Autoantibodies In Patients With Systemic Lupus Erythematosus. American Journal Of Gastroenterology 96 (2001):1113-5. In this study, the researchers found antigliadin antibodies in some individuals with Lupus. The IgA antiendomysial antibodies and scopes were negative, so the researchers thought the antigliadin results were false negatives. IgA antiendomysial antibodies correspond with the level of intestinal damage so this test would likely be negative considering that the scope results were negative (also could have a IgA deficiency). Many with CD do not have bowel involvement, so I think the positive antigliadin antibodies in this study could indicate that these people are gluten sensitive (similar to gluten ataxia).
71. Hadjivassilou et el. Gluten Sensitivity Masquerading As Systemic Lupus Erythematosus. Annals Of Rheumatic Diseases 63 (2004): 1501-3.
72. Peter Elfström*, Scott M. Montgomery, Olle Kämpe, Anders Ekbom, and Jonas F. Ludvigsson. Risk of primary adrenal insufficiency in patients with celiac disease. Journal of Clinical Endocrinology & Metabolism doi:10.1210/jc.2007-0960.
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